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Updated: Sep 9, 2025

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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SOCS1の枯渇は,ACTN4の分解を抑制することによって,骨肉腫の根性および化学抵抗を駆動する

Jin-Yan Feng1, Xian-Fu Wei1,2, Long Chen1

  • 1National Key Laboratory of Draggability Evaluation and Systematic Translational Medicine, Tianjin's Clinical Research Center for Cancer, Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China.

Acta pharmacologica Sinica
|September 1, 2025
PubMed
まとめ

サイトカインシグナル伝達1 (SOCS1) 抑制剤は,ACTN4を安定させることで,骨肉腫の幹性および化学抵抗性を促進する. SOCS1を回復させたり,ACTN4を阻害したりすると,治療結果が改善される可能性があります.

キーワード:
ACTN4 についてSOCS1 について化学過敏性オステオサルコマストームネスユビキチネーション

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