リクンシトは,食道がんの術前化学療法中の栄養失調と骨格筋喪失を弱める
Toshikatsu Tsuji1, Noriyuki Inaki2, Jun Kinoshita1
1Department of Gastrointestinal Surgery/Breast Surgery, Graduate School of Medical Science, Kanazawa University Hospital, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
Esophagus : official journal of the Japan Esophageal Society
|September 1, 2025
まとめ
術前の化学療法を受けている食道がん患者の体重,BMI,骨格筋の保存に役立ちます. この伝統的な日本の薬草は,がん治療中に栄養失調とサルコペニアを軽減する可能性を示しています.
科学分野:
- 腫瘍学
- 胃腸内科
- 薬理学について
背景:
- リクンシトは,化学療法による胃腸の問題を緩和する伝統的日本の薬草として知られています.
- 手術前にネオアジュバントまたは変換化学療法を受けている食道がん患者に対するその特定の影響は十分に確立されていません.
研究 の 目的:
- 術前化学療法を受けている食道がん患者の栄養状態と体質に対するリクンシトの効果を調査する.
- サルコペニアや体重減少などの治療に関連する副作用の軽減におけるリクンシトの潜在的役割を評価する.
主な方法:
- 術前化学療法と治癒手術を受けた57人の食道がん患者群を分析した.
- 患者はリクンシト群と対照群に分けられ,栄養状態はアルブミン,リンパ球数,PNI,GNRI,体重,BMI,骨格筋面積 (SMA) によって評価された.
- 傾向スコアマッチング (PSM) を使って,ベースラインの差異をコントロールした.
主要な成果:
- リクンシト群は,対照群と比較して体重とBMIの減少率が著しく低かった.
- 最初には統計的に有意ではなかったが,リクンシト群ではSMAの保存への傾向が観察された.
- PSMの後,リクンシト群は体重,BMI,特にSMAの減少を顕著に示しました.
結論:
- 食道がんのネオアジュバント化学療法中にリクンシトの投与は,骨格筋を含む身体の組成のより良い保存と関連しています.
- リクンシトは,重症治療を受けている食道がん患者において,サルコペニアと栄養低下との闘いにおいて貴重な補助療法として役立つ.
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