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Updated: Sep 9, 2025

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
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Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

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基礎IFN-λ2/3の発現は,ヒトの上皮細胞における緊密な結合形成を媒介する

Yagmur Keser1, Camila Metz-Zumaran1,2, Zina M Uckeley1

  • 1Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.

The EMBO journal
|September 1, 2025
PubMed
まとめ

基礎III型インターフェロン (IFN-λ) 発現は,上皮壁の整合性にとって極めて重要であり,緊密な結合の形成を促進する. この発現はcGAS-STING信号に依存し,Hippo経路によって調節されます.

キーワード:
基礎IFNλシグナリングエピテリア・バリア機能海馬 の 信号 経路狭い交差点cGAS-STING パスウェイ

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