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Updated: Sep 9, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

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共同マルチオーム単細胞DNA-RNA配列を用いたゲノム変異の機能的フェノタイプ化

Dominik Lindenhofer1,2, Julia R Bauman3, John A Hawkins1,4

  • 1Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.

Nature methods
|September 1, 2025
PubMed
まとめ

単細胞DNA-RNA配列解析 (SDR-seq) を開発し 遺伝子変異を遺伝子発現と結びつけました この方法では 遺伝子の多様性が 癌の進行などの 遺伝子活動や病気に影響を及ぼすことを明らかにします

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

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Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

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RNA-seq03:21

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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