関連する実験動画

Updated: Sep 9, 2025

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
09:45

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

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RM2 ベースの GRPR リガンドにおける Gln-Trp 部位の変化の影響に関する研究

Sebastian Fischer1, Lena Koller1, Sandra Dominelli1

  • 1TUM School of Natural Sciences, Department of Chemistry, Chair of Pharmaceutical Radiochemistry, Technical University of Munich, 85748, Garching, Germany.

EJNMMI research
|September 1, 2025
PubMed
まとめ

非自然なアミノ酸でガストリン放出ペプチド受容体 (GRPR) リガンドRM2を修正すると,その安定性と薬理学的な性質に影響する. α- メチル- L- トリプトファンアナログは,体内の安定性を改善し,GRPRを標的としたイメージングと治療の可能性を高めました.

キーワード:
対立者GRPR について代謝の安定性修正された薬剤RM2 について

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