攻撃的なノンホッジキンリンパ腫患者の患者の報告された症状の負担と健康関連の生活の質:横断的な研究
Jiayue Jin1,2, Simeng Ren1, Wei Zhang3
1Guang'anmen Hospital and China Academy of Chinese Medical Sciences, Beijing, China.
BMC cancer
|September 1, 2025
まとめ
症状の重さは,攻撃的なノンホッジキンリンパ腫 (NHL) の患者の健康関連生活の質 (HRQoL) に著しく影響します. コア・シンプトムズ・バード・セット (CSBS) のスコアは2. 50以上で,介入の必要性を示す.
科学分野:
- 腫瘍学
- 血液学
- 生活の質に関する研究
背景:
- 患者の報告した健康関連生活の質 (HRQoL) は,攻撃的な非ホジキンリンパ腫 (NHL) の生存予測要因の1つである.
- 症状の重さは,攻撃的なNHL患者のHRQoLと臨床結果に大きく影響する.
研究 の 目的:
- 攻撃的なNHLにおけるHRQoLに影響を与えるCore Symptoms Burden Set (CSBS) を調査する.
- 患者グループを区別するためにCSBSの臨床カットオフポイントを特定する.
主な方法:
- 116人の攻撃的なNHL患者の横断的な研究.
- 症状とHRQoLの評価のためにMDASI-TCMとEQ-5D-5Lを使用しました.
- CSBSの影響を分析し,カットオフポイントを決定するために多変数回帰とROC曲線を使用しました.
主要な成果:
- 睡眠障害,疲労,記憶障害は,CSBSで最も一般的な症状でした.
- CSBSは身体的および心理的な機能,EQ-5D指数,およびEQ VASに大きな影響を与えた.
- CSBSの最適な切除値は2. 50で,有意な臨床差は82. 4%の感度と64. 6%の特異性を示した.
結論:
- CSBSは,攻撃的なNHL患者のHRQoLに大きな影響を及ぼします.
- 2. 50以上のCSBSスコアは,臨床的注意と介入の予備指標として使用されます.
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