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Updated: May 5, 2026

Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury
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腰椎間板変性および臨床症状との相関の定量評価:超短時間エコーとT2マッピングをバイオマーカーとして使用した研究

Jun Han1, Xiang Hong Meng1, Zhilin Ji1

  • 1The Department of Radiology, Tianjin Hospital, Tianjin University, 406 Jiefang Southern Road, Tianjin, China.

BMC musculoskeletal disorders
|September 1, 2025
PubMed
まとめ

定量的なMRI T2*とT2マッピングは,腰椎軟骨の末端板 (CEP) の損傷と腰痛 (LBP) の重さを効果的に評価します. これらの高度なMRI技術は 従来のMRIと比較して 変性度および障害との優れた相関性を示しています

キーワード:
軟骨の端板椎間板変性T2マッピングウルトラショートエコータイム T2* マッピング

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Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
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Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
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The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
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