知識の翻訳プラットフォーム:ブローカー,仲介者,またはそれ以上? 定義,機能,特徴のスコーピングレビュー
B Schmidt1,2,3, C Mulopo4,5, L Mayieka6
1Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa. Bey-Marrie.Schmidt@mrc.ac.za.
Health research policy and systems
|September 1, 2025
まとめ
知識翻訳プラットフォーム (KTP) は,証拠に基づいた意思決定に不可欠ですが,一貫性のない定義です. このレビューは,KTPの定義と機能を調和させ,そのグローバルな影響と拡張性を強化します.
科学分野:
- 医療サービス研究
- 知識 翻訳
- 政策の実施
背景:
- 知識翻訳プラットフォーム (KTP) は,証拠に基づいた意思決定のための重要な仲介者です.
- グローバルKTPには標準化された定義と識別がなく,認識と協力が困難です.
- 不一致した記述は,KTPイニシアチブの学習,適応,スケーリングを制限します.
研究 の 目的:
- KTPの定義,機能,特徴に関する文献を統合する.
- KTP の理解と用語を調和させる.
- KTPの機能に関する改訂された枠組みを提案する.
主な方法:
- 推奨されたガイドラインを利用したスコーピングレビュー.
- 制限なくPubMed,Scopus,CINAHLで検索する
- ATLAS.tiを使用した対象研究のテーマ分析
主要な成果:
- ほとんどのKTPは自己認識をしていない.
- 共通のKTP要素には,プラットフォーム,利害関係者の関与,知識の翻訳活動,および健康に関する意思決定への貢献が含まれます.
- 資金提供者の関与と持続可能性の計画を含む,知識の交換,対話,能力を超えた拡張された機能を特定しました.
結論:
- KTPの統合された定義と拡張された機能的枠組みが開発されました.
- 持続的な投資と制度的支援は,KTPの影響を最大化するために不可欠です.
- 国家政策のエコシステムへの統合は,KTPの有効性にとって不可欠です.
関連する概念動画
Leaky Scanning
5.2K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.2K
Improving Translational Accuracy
2.7K
2.7K
Bioequivalence: Overview
1.2K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
1.2K
Ribosome Profiling
3.6K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.6K
Translational Regulation
91
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
91
Riboswitches
8.5K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
8.5K


