関連する実験動画

Updated: Sep 9, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

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GluN2Bを含むNMDA受容体のシナプス蓄積は,BDNF-TrkBのシグナリングがシナプス可塑性および状態の性における効果を媒介する

Pasqualino De Luca1,2,3, Miranda Mele1,2, Sara Tanqueiro4

  • 1CNC-UC - Center for Neuroscience and Cell Biology, and CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.

Journal of biomedical science
|September 1, 2025
PubMed
まとめ

脳由来神経栄養因子 (BDNF) は,シナプスのGluN2Bを含むNMDA受容体を増加させ,海馬のシナプス可塑性および記憶力を高めます. このメカニズムは長期にわたる増強に不可欠であり, epilepsy に関わっています.

キーワード:
BDNFについてエピレプシー海馬のシナプスLTP についてNMDA受容体

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