関連する実験動画
Updated: Sep 9, 2025

08:56
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
985
白血病の治療におけるCi Bai カプセルの潜在的な生物活性化合物群とメカニズムの探索:ネットワーク薬理学とトランスクリプトームの証拠の組み合わせ
Dingfan Zhang1, Congshu Huang2, Lei Zhou3
1Institute for TCM-X, MOE Key Laboratory of Bioinformatics/Bioinformatics Division, BNRIST, Department of Automation, Tsinghua University, Beijing, 100084, China.
Chinese medicine
|September 2, 2025
まとめ
Ci Bai Capsule (CB) は,主要な化合物と経路を特定することによって,放射線誘発性白血病と闘う. この伝統的な中国医学のアプローチは 免疫の回復を促進し 放射線に関連する血液疾患の 治療の可能性を提供します
科学分野:
- 薬理学について
- 免疫学
- 中国 伝統 医学
背景:
- 放射線被曝は白血病を引き起こし,しばしば"血液不足"や"疲労症候群"のようなTCM症候群と関連しています.
- Ci Bai Capsule (CB) は白血球の数を増やすことが知られているが,その活性成分とメカニズムは完全に理解されていない.
研究 の 目的:
- CB内の生物活性化合物を特定する
- CBが潜在的に放射線誘発性白血病を治療するメカニズムを解明する.
主な方法:
- SYMMAPとCTDのデータベースからデータを統合して,活性化合物と経路を特定するためにネットワーク薬理学を使用しました.
- ドラッグCIPHERは CBのターゲットプロフィールを予測した.
- 実験的検証には,フローサイトメトリー,RNAシーケンシング,RT-qPCR,およびウェスタンブロット in vivoおよび in vivoモデルが含まれていた.
主要な成果:
- 5つの重要な生物活性化合物が特定されました:カエンフェロール-3-グルコラムノシド,シリンジン,シサンドリン,3-ヒドロキシチロゾール3-O-グルコシド,サリドロシドです.
- これらの化合物は細胞プロセス,免疫応答,信号伝達に関連する22の経路を調節します.
- CB治療は白血球数と臓免疫細胞の増殖を高め,PP1A,RB,CDK4/6,CDK1などの主要標的を調節した.
結論:
- CBは放射線による白血病を効果的に軽減します.
- カプセルは,その生物活性化合物を介して免疫および血液形成の回復を促進します.
- CBは放射線関連の血液学的疾患に対する有望な治療戦略を示しています.
さらに関連する動画
関連する概念動画
Structure and Function of Leukocytes
2.4K
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
White blood cells protect the body...
2.4K
Disorders of Leukocytes
1.1K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.1K
Differentiation of Common Myeloid Progenitor Cells
3.3K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.3K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Classification of Leukocytes
2.6K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
2.6K

