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Updated: Sep 9, 2025

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

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Published on: March 24, 2017

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変形成長因子β (TGF-β) は,クロライド細胞内チャネル4 (CLIC4) を通して,全身性硬化症のケラチノサイトに1型インターフェロン信号を誘導する

Christopher W Wasson1, Sophie L Dibb2, Begoña Caballero-Ruiz2

  • 1Faculty of Medicine and Health, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK. c.w.wasson@leeds.ac.uk.

Arthritis research & therapy
|September 2, 2025
PubMed
まとめ

組織性硬化症 (Systemic sclerosis,SSc) は皮膚線維症と内臓の損傷を伴う. この研究は,SSc皮膚で観察された異変型1型インターフェロンシグナル伝達にクロライド細胞内チャネル4 (CLIC4) が重要なことを明らかにしています.

キーワード:
CLIC4 についてインターフェロンSTAT1 についてスクレロダーマ

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