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Updated: Sep 9, 2025

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

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発色性ビロノジュール性シノウィチスにおけるプロテオミクスとメタボロミクス研究は,ADGRE5-NF-κB経路による単細胞の分化調節を明らかにした

Minghao Ge1, Runze Yang1, Baojun Xu1

  • 1Sports Medicine Center, Department of Orthopedic Surgery/Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

BMC medicine
|September 2, 2025
PubMed
まとめ

皮質性ビロノドーラーシノビティス (PVNS) は,骨格細胞の分化と関節破壊を促す代謝変化と免疫細胞の浸透を伴う. ADGRE5とNF- kBを標的とした治療は,PVNS患者にとって新しい治療戦略を提供することができる.

キーワード:
メタボロミックオステオクラストの分化ピグメンテッド・ビロノドゥーラ・シノビティスプロテオミクス

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