ターナーおよびクラインフェルター症候群におけるエピジェネティックな年齢加速:臨床的老化マーカーとの相関
Emma B Hasselholm1,2, Jesper Just3,4, Simon Chang3,5
1Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark. emjo@clin.au.dk.
Clinical epigenetics
|September 2, 2025
まとめ
ターナー症候群 (TS) とクラインフェルター症候群 (KS) の生物学的老化は加速され,寿命の短縮と併発症を説明する可能性がある. 体組成の変化は,TSとKSの加速老化と相関しています.
科学分野:
- 内分泌学
- 遺伝学
- エピジェネティクス
背景:
- 性染色体動粒症,ターナー症候群 (TS) とクラインフェルター症候群 (KS) は,加齢の併発症と寿命の縮小に関連しています.
- ゲノム全体のDNAメチル化変化は,TSとKSにおける生物学的老化の増加を示唆する.
- エピジェネティック・クロックの調査は,これらの症候群における生理学的衰退と老化に関連する問題との関係を明らかにすることができます.
研究 の 目的:
- 対照群と比較してTSとKSの個体における生理学的老化を評価する.
- エピジェネティック年齢とTSとKSの臨床変数との相関性を探求する.
- これらの状態における老化の潜在的な臨床マーカーを特定する.
主な方法:
- TS (n=57) と女性対照群 (n=33) とKS (n=65) と男性対照群 (n=63) から得られたDNAメチル化データに対する表遺伝子時計の適用
- エピジェネティック年齢と臨床パラメータの相関の評価
- エストロゲン置換療法の生物学的年齢への影響の分析
主要な成果:
- エピジェネティック・クロックは,対照群と比較して,一貫してTSの進行した生物学的老化を示した.
- エピジェネティック・クロックは KSの加速老化を示唆していますが 証拠はそれほど顕著ではありませんでした
- エストロゲン置換療法では,TS患者の生物学的な年齢が低下することが示されました.
- 身体の不良な構成は,対照群の年代的年齢と相関しているが,TSとKSの老化率と相関している.
結論:
- 生物学的老化は,TSとKS,特にTSにおいて著しく増加し,寿命の縮小に寄与する.
- TSとKSの加速された老化は,特に低子腺症の不良な体調の変化と関連している可能性があります.
- エピジェネティック・クロックは 性染色体アヌプロイドの 加速した老化過程の洞察を提供します
さらに関連する動画
09:39Generation of Induced Pluripotent Stem Cells from Turner Syndrome 45XO Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
Published on: December 4, 2021
3.2K
12:08Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
Published on: May 22, 2013
46.7K
関連する概念動画
Epigenetic Regulation
3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.1K
Aging
179
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
179
Nondisjunction
4.1K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
4.1K
Meiosis vs. Mitosis
58.1K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
58.1K
Gene-Environment Interactions
433
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
433
Meiosis I
41.3K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
41.3K
