75歳以上の胃がん患者におけるヘリコバクター・ピロリ感染症とメタクロノス胃がん
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PubMedで要約を見る
まとめ
この要約は機械生成です。ヘリコバクター・パイロリ (Hp) 感染が老年患者で持続すると,内視鏡による下粘膜解剖後のメタクロン胃がんのリスクが増加します. これらの患者にはHP治療が推奨されます.
科学分野
- 胃腸内科
- 腫瘍学
- 感染症
背景
- ヘリコバクター・パイロリ (Hp) 感染症は,早期の胃がん (EGC) のメタクロン胃がん (GC) の末尾膜下解剖 (ESD) と関連しています.
- 高齢者 (≥75歳) の患者では,この関連性が理解されていない.
研究 の 目的
- 高齢EGC患者におけるHP感染状態とESD後のメタクロノスGC発達の関連性を調査する.
主な方法
- ESDを受けた75歳以上のEGC患者298人を遡及分析した.
- 患者はHP陰性 (n=233) とHP陽性 (n=65) グループに分けられた.
- 主なアウトカムは,ESDの1年後に診断されたメタクロノスGCでした.
主要な成果
- メタクロノスGCは,Hp陰性患者の6. 9%とHp陽性患者の15. 4%で発生した.
- メタクロンがんの発生率は,Hp陽性群で有意に高かった (p=0. 035).
- 持続的なHP感染はメタクロン性GCの独立リスク因子であった (aHR=2. 33).
結論
- 恒常的なH. pylori感染は,EGCのためにESDを受ける高齢者の胃がんのリスク増加と関連しています.
- 高齢者 (75歳以上) のEGC患者では,このリスクを軽減するためにH. pylori治療を考慮する必要があります.
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