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関連する概念動画

Caspases01:24

Caspases

12.7K
Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
12.7K
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

211
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
211
Distribution Reliability and Automation01:25

Distribution Reliability and Automation

153
Distribution reliability in electrical power systems is critical for ensuring an uninterrupted power supply to consumers at minimal cost. According to IEEE Standard Terms, reliability is the probability that a device will function without failure over a specified time period or amount of usage. For electric power distribution, this translates to maintaining continuous power supply and addressing customer concerns over power outages. Several indices, as defined by IEEE Standard 1366-2012, are...
153
CRISPR01:59

CRISPR

52.9K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
52.9K
CRISPR and crRNAs02:53

CRISPR and crRNAs

17.3K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
17.3K
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

3.3K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
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関連する実験動画

Updated: Sep 9, 2025

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
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Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

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2024年のCASPインフラストラクチャの更新

Andriy Kryshtafovych1, Maciej Milostan2, Marc F Lensink3

  • 1Genome Center, University of California, Davis, Davis, California, USA.

Proteins
|September 2, 2025
PubMed
まとめ
この要約は機械生成です。

構造予測の批判的評価 (Critical Assessment of Structure Prediction,CASP) のデータシステムは,CAPRIシステムと統合され,マクロ分子構造の予測を進めるため,CASP16で更新されました.

キーワード:
3D構造の予測CASP16 についてRNA構造代替形状タンパク質構造タンパク質・リガンド複合体

さらに関連する動画

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
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Evaluation of Caspase Activation to Assess Innate Immune Cell Death

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Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
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Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

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関連する実験動画

Last Updated: Sep 9, 2025

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

19.6K
Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

3.4K
Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

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科学分野:

  • 計算生物学
  • 構造生物学
  • バイオ情報学

背景:

  • 構造予測の批判的評価 (Critical Assessment of Structure Prediction,CASP) は,マクロ分子構造予測の最先端を評価するためのコミュニティ実験である.
  • CASPのデータ管理システムは,これらの実験の要求を満たすために継続的な進化を必要とします.

研究 の 目的:

  • CASP16実験のためのインフラストラクチャの強化を詳細に説明します.
  • CASPとCAPRI (Critical Assessment of PRedicted Interactions) の統合を文書化する

主な方法:

  • CASPのデータ処理インフラを拡張する.
  • CASP15から新たに導入されたパイロットカテゴリーへの支援を組み込む.
  • CASPとCAPRIのデータ管理システムを統合する

主要な成果:

  • CASPのデータ管理システムは,CASP16に拡張されました.
  • CASP15からの新しいカテゴリーとパイロットカテゴリーは,現在完全にサポートされています.
  • 現在,CASPとCAPRIシステムは統合されています.

結論:

  • 更新されたCASPデータ管理システムは,マクロ分子構造予測実験の需要を効果的にサポートしています.
  • CAPRIとの統合は,構造予測と並行して,予測された相互作用のより包括的な評価を容易にする.