母乳プロテオーム:哺乳期のさまざまな段階における変化と妊娠中の糖尿病と体量指数の影響

Timo Seitz^1,2, Jenni Viitaharju³, Chouaib Benchraka⁴

¹Nutrition and Food Research Center, Faculty of Medicine, University of Turku, Turku, Finland.

Molecular nutrition & food research

|September 2, 2025

まとめ

母親の妊娠糖尿病 (GDM) と体量指数 (BMI) は母乳のタンパク質を変化させる. これらの変化は乳児の発達に影響し,GDMと高いBMIを持つ母親の成熟した乳に特定のタンパク質が増加します.

科学分野:

プロテオミクス
人間生物学
代謝健康

背景:

母乳には乳児の発達に不可欠な生物活性タンパク質が含まれています
妊娠糖尿病 (GDM) や体量指数 (BMI) などの母親の代謝状態が母乳タンパク質に及ぼす影響は十分に理解されていません.

研究の目的:

コロストラムから成熟した牛乳への母乳プロテオムの変化を調査する.
母親のGDMとBMIが母乳プロテオームに与える影響を調べる

主な方法:

データ独立取得 (DIA) ベースのLC-MS/MSを用いたプロテオミック分析.
異なるBMIとGDM状態の47人の母親から採取した乳牛乳と成熟乳の分析

主要な成果:

3496のタンパク質が特定され,その1055はコロストラムと成熟した牛乳の間で多様である.
コロストラムは免疫および粘着に関連するタンパク質に富み,成熟した牛乳は生物合成および分解タンパク質に富んでいました.
GDMとBMIが高い母親は成熟した牛乳でHDL形成に関連するタンパク質のレベルが上昇した.

結論:

母親のBMIとGDMは母乳プロテオームに大きな影響を及ぼします.
成熟した牛乳の特定のプロテオミクスの変化は,GDMと高いBMIと関連しています.
乳児の健康に対するこれらのタンパク質学的変化の臨床的影響を明らかにするためにさらなる研究が必要である.

キーワード:

体重指数母乳妊娠中の糖尿病プロテオーム

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