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Updated: Sep 9, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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新たに診断された多発性骨髄腫の治療におけるボルテゾミブの有害事象に影響を与える要因の決定

Mengmeng Dong1, Xiaoyan Han1, Jingsong He1

  • 1Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

Hematology (Amsterdam, Netherlands)
|September 2, 2025
PubMed
まとめ

多発性骨髄腫患者では,皮下用ボルテゾミブは,静脈内投与と比較して,周辺神経症や感染症などの有害事象を減少させる. 投与量を減らすと感染のリスクは増加しますが,有効性には大きな影響はありません.

キーワード:
DS ステージ多発性骨髄腫有害事象ボルテゾミブ投与量効能について感染症皮膚下に注射する治療法

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Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
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