口腔状細胞癌の高齢患者における年齢と治療戦略の予後的影響: 11年後の分析
Yuki Oikawa1, Shoken Suzuki1, Hidemitsu Igarashi1
1Department of Dentistry and Oral Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Head & neck
|September 2, 2025
まとめ
高齢の口腔がん患者の生存率を向上させる. 健康状態を考慮して個別化された治療は,高齢者の口腔状細胞癌 (OSCC) 管理の鍵です.
科学分野:
- 腫瘍学
- 高齢者医療
- 口腔 外科
背景:
- 口腔状細胞癌 (OSCC) の発生率は,特に日本では高齢者集団で増加しています.
- 高齢者はOSCCの影響を受ける人口の増加を代表しています.
研究 の 目的:
- 高齢者 (≥75歳) と非高齢者 (<75歳) のOSCC患者の予後結果を比較する.
- 老年OSCC患者の生存に対する治療目的 (治癒 vs 緩和) の影響を評価する.
主な方法:
- 秋田大学病院で治療を受けた312人のOSCC患者 (2011年-2021年) の遡及分析.
- 患者様を高齢者と非高齢者に分ける.
- 年齢と治療の意図に基づく疾患特異生存率 (DSS) と全生存率 (OS) の比較
主要な成果:
- 治療目的の治療を受けた高齢患者は,緩和目的の治療を受けた患者と比較して, signicantly better DSS and OS を示した.
- 高齢者群の疾患特異生存率は83. 2%で,治療目的の場合は90. 5%で,緩和目的の場合は2. 9%でした.
- 高齢のOSCC患者では,治療目的による生存効果が著しく示された.
結論:
- 高齢のOSCC患者にとって,高度な段階であっても,個別化された治療は極めて重要です.
- 治癒の意図は,一般的に受け入れられる健康状態の高齢者に好ましい結果をもたらします.
- 重度の併発性疾患を有する高齢者の場合,生活の質を優先して緩和的な治療を考慮する必要があります.
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