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Updated: Sep 9, 2025

Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol
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トリプトファン・カタボリト経路は,重症および単純な神経認知症における二刃の剣である

Hussein Kadhem Al-Hakeim1,2,3, Ameer Abdul Razzaq Al-Issa3, Chen Chen1,2

  • 1Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.

Acta neuropsychiatrica
|September 2, 2025
PubMed
まとめ

重症神経認知症 (MNP) と単純な神経認知症 (SNP) は,血清トリプトファンカタボリート (TRYCAT) の異なるプロファイルを示しています. MNP患者にはトリプトファン,キヌレン酸,3-OH-アンスラニル酸が低く,アンスラニル酸とキノリニル酸が高く,SNPと対照群と区別されます.

キーワード:
バイオマーカー炎症神経免疫酸化ストレス統合失調症トリプトファン

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