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Updated: Sep 9, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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核毛孔複合体の選択的分解剤としての臨床段階の化合物の抗腫瘍作用機構の定義

Linjie Yuan1, Wenzhi Ji2, Brendan G Dwyer2

  • 1Stanford University, Palo Alto, CA, United States.

Cancer discovery
|September 2, 2025
PubMed
まとめ

PRLX-93936という 新種の分子接着剤が 癌細胞の核孔複合体を標的としています この薬はTRIM21をプログラムし,核の毛穴を分解し,がん細胞のアポトーシスを誘発し,臓がんモデルで有効性を示しています.

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