異なる年齢の女性患者でIVF/ICSI (体外受精/細胞内精子注射) の累積生育率の臨床予測モデルを構築する
Chunya Ye1, Panhavolak Chhoon1, Hedong Lu1
1Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University) Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China.
Reproduction & fertility
|September 2, 2025
まとめ
この研究は,体外受精 (IVF) または細胞内精子注射 (ICSI) の後の生育率の年齢特有の予測モデルを開発した. このモデルは卵子採取数を最適化し 成功を最大化し 異なる年齢の女性にとってのリスクを最小限にします
科学分野:
- 生殖医学
- 臨床予測モデリング
- 不妊 症 の 治療
背景:
- 妊娠の遅延は 妊活に悪影響を及ぼし,IVFやICSIのような 高度な治療が必要になります
- 卵の量と質は 年齢とともに低下し 妊娠の成功率が低下します
- 卵子採取を最適化することは 助産技術での生育結果を最大化するために不可欠です
研究 の 目的:
- IVF/ICSI後の累積生児率の臨床予測モデルを開発する.
- 患者の年齢を基に 生後予測の鍵となる要因を特定する
- 生殖の成功を高めるために,卵を採取するための年齢特有の推奨事項を提供すること.
主な方法:
- 年齢によって分類されたIVF/ICSIを受けた374人の不妊女性の分析 (<35,35-39,≥40).
- 予測モデリングのために最小絶対縮小と選択演算子 (LASSO) の回帰を使用した.
- 線形回帰を用いて 採取された卵の量と 生産の確率を相関させました
主要な成果:
- 女性<35,15個の卵を採取した結果,生児誕生の確率は99%で,メタフェーズIIの卵とブラストキストが重要な予測指標でした.
- 35歳から39歳までの女性では,卵子とメタフェーズIIの卵子数によって影響を受け,採取卵子20個で生育の確率は90%であった.
- 採取された14個の卵子は,採取量の主要な要因として,生児の50%の確率を予測した.
結論:
- 開発されたモデルは,最適な卵回収数に関する年齢に合わせたガイドラインを提供します.
- パーソナライズされた推薦は,IVF/ICSIの成功率を高めることができます.
- このモデルは卵巣の過剰刺激のリスクを減らすのに役立ちます.
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