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関連する概念動画

Exocytosis00:50

Exocytosis

7.1K
Exocytosis is a process that releases molecules outside the cell. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis is the opposite of endocytosis, which brings molecules inside the cell. Sometimes, the released materials are signaling molecules. For example, neurons typically use exocytosis to release neurotransmitters. Cells also use exocytosis to insert proteins such as ion channels into their cell membranes, secrete proteins for use in the extracellular matrix, or...
7.1K
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

8.6K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
8.6K
Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis01:18

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

1.5K
Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell...
1.5K
Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

11.7K
Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
11.7K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

2.6K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
2.6K
Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

3.2K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
3.2K

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関連する実験動画

Updated: Sep 9, 2025

Monitoring the Effect of Osmotic Stress on Secretory Vesicles and Exocytosis
08:08

Monitoring the Effect of Osmotic Stress on Secretory Vesicles and Exocytosis

Published on: February 19, 2018

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運動はエクソサイトーシスを調節する:細胞内小胞の視点からの化学的洞察

Ran Liu1, Xiulan He1, Jing Liu1

  • 1College of Chemistry, Beijing Normal University, Beijing, 100875, China.

Angewandte Chemie (International ed. in English)
|September 2, 2025
PubMed
まとめ

運動は神経伝達物質の蓄積と放出を増加させ,運動に関する新しい洞察を提供することで,細胞内膀の機能を高めます.

キーワード:
カテコラミンの放出運動補助金シングルベシクル電気化学膀型貯蔵

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Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
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Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

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Automated Detection and Analysis of Exocytosis
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Automated Detection and Analysis of Exocytosis

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関連する実験動画

Last Updated: Sep 9, 2025

Monitoring the Effect of Osmotic Stress on Secretory Vesicles and Exocytosis
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Monitoring the Effect of Osmotic Stress on Secretory Vesicles and Exocytosis

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Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
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Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells

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Automated Detection and Analysis of Exocytosis
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科学分野:

  • 神経科学
  • 細胞生物学
  • 運動 生理学

背景:

  • 運動の全身的効果は 細胞外小胞を通して放出されるエクサキンと関連しています
  • 運動が神経伝達物質の動態を含む細胞内膀の化学反応に与える影響は十分に理解されていません.

研究 の 目的:

  • 神経伝達物質の貯蔵とエクソサイト動力学に焦点を当てて,運動が細胞内膀化学をどのように調節するかを調査する.
  • 運動による膀機能の変化の仕組みを解明する.

主な方法:

  • 細胞内小胞の化学分析に単一小胞の電気化学を用いた.
  • 運動によるエクソサイトーシスに関与するタンパク質とイオン流を特定するためのメカニズム研究を行った.

主要な成果:

  • 運動は神経伝達物質の貯蔵容量と 細胞内小胞からの放出を高めます
  • 運動は放出分数のわずかな減少で,エクソサイトーシスの期間を短縮します.
  • エクソサイトーシスに関連したタンパク質の上昇とカルシウム流入の増加が主要なメカニズムとして特定されました.

結論:

  • 運動は細胞内膀の化学反応を大きく変化させ,神経伝達物質の貯蔵と放出のダイナミクスを影響する.
  • これらの発見は 運動の生理学的効果について 新しい化学的洞察をもたらします
  • これらのメカニズムを理解することは,生理学的および病理学的プロセスにおける運動の役割を理解するために不可欠です.