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Updated: Sep 9, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

7.0K

光学的に活性な環状化合物,リボン形およびプロペラ形化合物の合成,平面キラル [2.2]パラサイクロファン

Ena Kumamoto1, Nanami Miki1, Ryo Inoue2

  • 1Department of Applied Chemistry for Environment, School of Biological and Environmental Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, 669-1330, Hyogo, Japan.

ChemPlusChem
|September 2, 2025
PubMed
まとめ

研究者は平面キラル [2.2]パラサイクロファンを用いて光学的に活性な循環化合物を合成した. これらの分子は,高度な光学アプリケーションの可能性を示す強力な循環的偏光 (CPL) を表しています.

キーワード:
[2.2]パラサイクロファン円形の偏光平面キラリティ二次構造

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Solid-phase Synthesis of [4.4] Spirocyclic Oximes05:15

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Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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Stereoisomerism of Cyclic Compounds

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Photochemical Electrocyclic Reactions: Stereochemistry

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Molecules with Multiple Chiral Centers

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Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
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Thermal Electrocyclic Reactions: Stereochemistry

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Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
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