転移性乳がんの女性における不眠症に対する認知療法の効果
Claudia Mc Brearty1,2,3, Josée Savard1,2,3
1School of Psychology, Université Laval, Quebec, Canada.
Behavioral sleep medicine
|September 2, 2025
まとめ
認知療法 (CT) は,転移性乳がんとうつ病の女性における不眠症を有意に軽減しました. しかし,不眠症の残留症状は,追加の標的治療の必要性を示す.
科学分野:
- 腫瘍学
- 精神科
- 心理学
背景:
- 転移性乳がん (MBC) はしばしばうつ病や不眠症と併発する.
- 不眠症は,MBCの患者の生活の質に大きな影響を及ぼします.
- 併発性うつ病と不眠症の効果的な管理は,MBC患者にとって極めて重要です.
研究 の 目的:
- MBCの女性における不眠症の症状を緩和する認知療法 (CT) の有効性を評価する.
- この患者集団における不眠症の重度に対するCTの長期的効果を評価する.
主な方法:
- MBCとうつ病の症状を持つ34人の女性を対象としたランダム化比較試験です.
- 参加者はうつ病のCTまたは待機リストのコントロール (WLC) に割り当てられました.
- 不眠症の重症度指数 (ISI) は,治療前の,治療後の,および3ヶ月および6ヶ月後のフォローアップで測定されました.
主要な成果:
- 治療後の臨床的に有意な不眠症の割合は 80. 0% から 26. 7% に大幅に減少した.
- 治療後のWLCと比較して,CT群の平均ISIスコアは有意に低下した (5. 5 対 12. 7).
- 統合された分析では,治療後6ヶ月間,不眠症の症状が持続的に改善されたことが示された.
結論:
- うつ病に対する認知療法は,転移性乳がんの女性における不眠症の軽減に有効であることが示されています.
- 患者の有意な割合 (21. 0% - 46. 3%) がCT後に残留不眠症の症状を経験した.
- うつ病と不眠症が併発する女性には,特に不眠症を標的とした併用治療が推奨されます.
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