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Updated: Sep 9, 2025

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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CLDN4は,急性炎において,JAK2/STAT3経路を含むフェロプトーシスおよび炎症を促進する

Chuanming Zheng1, Rui Tao1, Zhenjie Wang1

  • 1Department of Emergency Surgery, The First Affiliated Hospital of Bengbu Medical University, No. 801 Zhihuai Road, Longzihu District, Bengbu, 233000, Anhui, China.

Functional & integrative genomics
|September 2, 2025
PubMed
まとめ

クラウジン-4 (CLDN4) の上昇は,急性炎 (AP) のフェロプトーシスと炎症を誘発する. CLDN4の減少は,フェロプトーシスを抑制し,JAK2/ STAT3経路を阻害することによって,臓の損傷から保護します.

キーワード:
急性炎CLDN4 についてフェロプトーシスJAK2/STAT3信号経路について臓のアシナ細胞

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