インドメタシン誘発の胃潰瘍に対するヘーゼルナッツ抽出物の効果を調査する:抗酸化および胃保護の可能性
Yusuf Öztürk1, Fadime Atalay Dumlu2, Özlem Aydın Berktaş3
1Faculty of Vocational School of Technical Sciences, Department of Hotel Restaurant and Catering Services, Ardahan, 75002, Turkey. yusufozturk000@hotmail.com.
Plant foods for human nutrition (Dordrecht, Netherlands)
|September 2, 2025
まとめ
ハーゼルナッツのエキスは,特にトラブゾンから,強力な抗酸化物質と胃保護効果を示します. 胃潰瘍を大幅に減らし 酸化ストレスに対する 身体の自然防御を強化します
科学分野:
- 植物化学
- 薬理学について
- 栄養薬
背景:
- 胃潰瘍は健康上の重大な問題であり,しばしば酸化ストレスによって悪化します.
- 自然化合物は,胃腸疾患の管理における治療の可能性についてますます研究されています.
- ハーゼルナッツ (Corylus avellana) は,抗酸化物質を含む豊富な栄養プロファイルで知られています.
研究 の 目的:
- 様々なハゼルナッツの抗酸化効果と胃保護効果を評価する.
- 最強のハゼルナッツのエキスを 治療用として特定する
- 胃潰瘍のモデルにおける酸化ストレスの生化学的マーカーに対するハゼルナッツのエキスの影響を調査する.
主な方法:
- ネズミの胃潰瘍を誘導する インドメタシン
- トラブゾンハズルナッツのメタノール抽出物を中心に,異なるハズルナッツ抽出物を投与する.
- 脂質過酸化抑制による抗酸化作用の評価
- 潰瘍指数による胃保護効果の測定
- 主要な抗酸化酵素の分析:カタラゼとグルタチオンのレベル
主要な成果:
- トラブゾンハズルナットのメタノール抽出物は,最も高い抗酸化活性 (86. 0%の脂質過酸化阻害) とフェノール含有量を示した.
- トラブゾンメタノール抽出物は,インドメタシン誘発の胃潰瘍領域を著しく減少させ,トラブゾンメタノール抽出物は,潰瘍指数を100 mg/ kgで90. 6%減少させた.
- 抽出物は,カタラーゼ活性を増やし,脂質過酸化を減らし,グルタチオンのレベルを回復することによって,抗酸化防御を強化しました.
結論:
- ハーゼルナッツのエキスは,重要な抗酸化物質と胃保護性を持っています.
- トラブゾンハズルナッツメタノール抽出物は胃潰瘍と酸化ストレス関連疾患に対する有望な治療の可能性を示しています.
- ハーゼルナッツの効果を最大限活用するには メカニズムや臨床試験や食品への応用に関するさらなる研究が必要です
関連する概念動画
01:28Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
569
Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
569
01:20Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
595
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
595
01:17Gastritis-II: Pathophysiology
542
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
542
01:23Gastritis III: Clinical Manifestations and Management
466
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
466
01:13Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
525
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
525
01:26Peptic Ulcer Disease IV: Management
145
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
145