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関連する概念動画

Membrane Asymmetry Regulating Transporters01:19

Membrane Asymmetry Regulating Transporters

4.9K
Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
4.9K
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

7.4K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
7.4K
Transport Across the Golgi01:26

Transport Across the Golgi

4.4K
While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
4.4K
Fluid Mosaic Model01:19

Fluid Mosaic Model

12.8K
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
12.8K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.1K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.1K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

2.6K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
2.6K

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関連する実験動画

Updated: Sep 9, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

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TS2CGは膜構築剤として

Fabian Schuhmann1, Jan A Stevens2, Neda Rahmani1

  • 1Niels Bohr International Academy, Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, Copenhagen 2100, Denmark.

Journal of chemical theory and computation
|September 2, 2025
PubMed
まとめ
この要約は機械生成です。

TS2CG バージョン2は,分子ダイナミクスシミュレーションのための粗粒子の膜構造を効率的に構築します. このツールは精密な脂質とタンパク質の配置を可能にし,複雑な全細胞モデリングと大規模な膜シミュレーションを容易にする.

さらに関連する動画

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
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Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

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Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs
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Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs

Published on: February 5, 2022

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関連する実験動画

Last Updated: Sep 9, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

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Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
06:32

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

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Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs
09:45

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs

Published on: February 5, 2022

3.7K

科学分野:

  • 計算生物学
  • バイオ物理学
  • 材料科学

背景:

  • 分子ダイナミクス (MD) のシミュレーションには,明確に定義された初期構造が必要です.
  • 現在のMD方法は,複雑な初期構造要件のために,全細胞モデリングで課題に直面しています.
  • 大規模でほぼバランスのとれた膜構造を 構築するには 効率的なツールが必要です

研究 の 目的:

  • TS2CG バージョン 2 を導入し,粗粒の膜構造を構築する.
  • リピッドとタンパク質の正確な配置を曲線の好みに基づいて可能にします.
  • 先進的なシミュレーションのための複雑な膜アーキテクチャの作成を容易にする.

主な方法:

  • TS2CGバージョン2は,高性能のためにC++コアを使用しています.
  • Python インターフェイスは拡張機能とカスタマイズを可能にします.
  • このツールは,制御された孔の生成と,膜の端に脂質の配置をサポートします.

主要な成果:

  • TS2CGバージョン2は,望ましい形状と横の組織を持つ膜構造を成功裏に構築します.
  • 証明された能力には,モビウス帯のモデル化,脂質ドメインとミトコンドリア膜を持つ"マルティニ球"の膀が含まれています.
  • シミュレーションは,膜の曲線の影響による脂質異質性を示しています.

結論:

  • TS2CG バージョン2は,複雑な粗粒子の膜モデルを構築するための強力なツールです.
  • 大規模な全細胞MDシミュレーションの実現性を大幅に向上させる.
  • このソフトウェアは,研究者が膜生物物理学を研究するための柔軟なプラットフォームを提供します.