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網膜静脈閉塞誘発性黄斑腫に対するラニビズマブと併用したジューリング・ミンム・デコクション: ランダム化制御臨床試験
Wu Hongyan1, Zhou Yao1, Zhou Hangshuai2
1Department of Ophthalmology, Dongyang People's Hospital, NO.60 Wu Ning Xi Road, Dongyang, Zhejiang, China.
International ophthalmology
|September 2, 2025
まとめ
Jueling Mingmu Decoctionとラニビズマブを併用すると,視力改善と網膜静脈閉塞 (RVO) 患者,特に枝状RVO患者における網膜腫の減少の可能性が示されています. このアプローチはラニビズマブ注射の必要性を有意に減少させなかった.
科学分野:
- 眼科について
- 統合医療
- 薬理学について
背景:
- 網膜静脈閉塞 (RVO) は視力喪失の主な原因です.
- 黄斑腫 (ME) は,RVOの一般的な合併症で,視力の低下につながります.
- 現在,RVO関連のMEの治療には,血管内皮成長因子 (VEGF) 治療が含まれています.
研究 の 目的:
- RVOに関連したMEの治療におけるラニビズマブと併用したJueling Mingmu Decoctionの有効性を評価する.
- 治療結果と注射頻度に関して,ラニビズマブ単独治療と併用治療を比較する.
主な方法:
- 予期せぬ ランダム化 制御された 評価者盲目の優越性試験です
- 治療前のRVO患者111人をラニビズマブ単独療法または併用療法 (ラニビズマブ+ジューリング・ミンム・デコクション) の2つのグループにランダムに分けました.
- 主要アウトカム: 48週間の内視内注射数 副次的なアウトカム: 最良の視覚鋭度 (BCVA) と中央部分フィールドの厚さ (CST).
主要な成果:
- モノセラピーとコンビネーションのグループでは,静脈内注射の数の有意な差はありません.
- 両群ともBCVAとCSTの有意な改善を示した.
- 併用グループでは,単体治療と比較して,特定の時間帯でBCVAの改善とCSTの低下が示されました.
結論:
- 組み合わせたJueling Mingmu Decoctionとラニビズマブ療法は,RVOに関連するME,特にBRVOにおける視覚的および解剖学的結果の改善に有望である.
- 併用療法では,ラニビズマブ注射の頻度は,単独療法と比較して減少しませんでした.
- 効果を確認し,長期的な安全性を評価するために,さらなる研究が必要である.
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