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Updated: Sep 9, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
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コリン塩化物ベースの深層溶媒を用いた薬剤の溶解性に対する機能群の影響

Prathiksha Prabhakar1, Anantharaj Ramalingam2

  • 1Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Rajiv Gandhi Salai (OMR), Kalavakkam, Chennai, Tamil Nadu, 603110, India.

Journal of molecular modeling
|September 2, 2025
PubMed
まとめ

深層エウテクティック溶媒 (DES) は,溶解性が低い薬剤を溶解させるのに有望である. コリン塩化物 (ChCl) は,特定の水素結合ドナーと組み合わせて,分子相互作用を活用することで,薬剤の溶解性を効果的に高めます.

キーワード:
COSMO-RSモデルコリン塩化物の機能群シグマポテンシャルシグマプロファイル水に溶けない薬

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