症例340:クローン病の肺症状としての肺性ネクロビオティックノードル

Nuno Lupi Manso^1,2, José Laert¹, Tomás França de Santana¹

¹Department of Radiology, Hospital CUF Tejo, Avenida 24 de Julho 171A, 1350-352 Lisbon, Portugal.

Radiology

|September 2, 2025

まとめ

クローン病の患者は,インフリキシマブ投与を中止した後,肺の損傷を発症した. 治療に関連した肺合併症の可能性を示唆する,胸痛と呼吸不全の持続性により,さらなる調査が求められました.

科学分野:

胃腸内科
肺科
免疫学

背景:

クローン病は慢性炎症です
インフリキシマブは,クローン病に対する一般的な生物学的治療法です.
肺の合併症は,クローン病またはその治療から生じることがあります.

研究の目的:

肺の損傷を起こすクローン病の患者を報告する
クローン病の治療と肺異常との潜在的な関連を調査する.
このような場合の診断上の課題を強調する.

主な方法:

クローン病の36歳の女性の症例報告です
インフリキシマブ,アザチオプリン,メサラジンの使用を含む病歴のレビュー
腹部と胸部CTスキャンを含む診断画像
胸痛と呼吸不全の臨床表現

主要な成果:

患者はインフリキシマブで治療された中等から重度のクローン病を発症した.
アザチオプリンとメサラジンによる治療が中止されました.
肺の病変は偶然に腹部CTで観察され,その後胸部症状のために調査されました.
症状が再発すると胸部CTを繰り返しバイオプシの結果を待った.

結論:

このケースは,インフリキシマブ治療後のクローン病患者の肺合併症の可能性を強調しています.
肺の損傷の性質を決定するために,生検を含むさらなる調査が必要と判断された.
このケースは,呼吸器系の症状を呈するクローン病患者の肺関節の関与を考慮する重要性を強調しています.

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