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Updated: May 3, 2026

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli
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Published on: November 4, 2022

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MPOで固定されたENO1は,セプシス中にIFITM2経由でTreg分化を促進するために中性細胞外トラップDNAを媒介する

Yi Jiang1, Shenjia Gao1, Xiya Li1

  • 1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.

The Journal of clinical investigation
|September 2, 2025
PubMed
まとめ

中性粒子の細胞外トラップ (NETs) は,エノラーゼ1 (ENO1) とIFITM2を通じ,免疫抑制を促すT細胞の調節機能 (Treg) を強化する. ENO1を阻害すると,マウスのセプシスが緩和され,新たな治療目標が明らかになる.

キーワード:
免疫学免疫療法感染症T細胞の発達

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