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Updated: Sep 9, 2025

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
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A20の線形ユビキチン結合モチーフは,Th17細胞の病原性活性化とIL-22誘発性腸炎を抑制する

Christopher J Bowman1,2, Dorothea M Stibor1, Xiaofei Sun1

  • 1Department of Medicine.

The Journal of clinical investigation
|September 2, 2025
PubMed
まとめ

タンパク質A20はTヘルパー17 (Th17) 細胞の膨張とインタールイキン22 (IL-22) 細胞の産生を調節し,腸炎の予防に不可欠です. A20の変異はIL-22による腸炎を引き起こす.

キーワード:
適応免疫胃腸内科免疫学炎症性腸疾患

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