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Updated: Jun 14, 2026

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SLC6A8によるクレアチンの吸収は,ERK2-FSP1のシグナル伝達を抑制し,大腸がんにおけるフェロプトーシスを誘発する

Xiaojun Zhou1, Genxin Wang1, Yuhang Wu1

  • 1Department of Colorectal and Anal Surgery, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, China; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, China.

Cell reports
|September 2, 2025
PubMed
まとめ

クレアチンは,ERK2媒介のFSP1の安定化を阻害することで,結腸直腸がんにおけるフェロプトーシスを誘発する. クレアチンのサプリメントは,腫瘍の成長を抑制し,T細胞の浸透を促進することで,がん免疫療法における治療的可能性を示しています.

キーワード:
CP: 癌についてCP: 代謝クレアチンフェロプトーシスチェックポイントの封鎖腫瘍の代謝再プログラム

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