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アジア系アメリカ人集団における膀がんのアウトカムにおける格差を明らかにする
Wenjin An1,2, Dong Shen1,2, Dan Li1,2
1Department of General Surgery, Jiangnan Hospital affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Expert review of anticancer therapy
|September 2, 2025
まとめ
膀癌 (UCUB) の生存率は,非ヒスパニック系アジア系アメリカ人 (NHAA) のサブグループ間で著しく異なります. 中国人と韓国人は 予後が良い一方で フィリピン人アメリカ人は 予後が悪いので 適した治療が必要になります
科学分野:
- 腫瘍学
- 流行病学
- 健康 の 格差
背景:
- 膀癌 (UCUB) 研究は,非ヒスパニック系アジア系アメリカ人 (NHAA) 集団内の民族間の違いをしばしば見過ごしている.
- この集約は,UCUBの特徴と様々なNHAAサブグループ間の結果の重要な違いを隠しています.
研究 の 目的:
- 異なるNHAAサブグループにおけるUCUB発生率,治療,生存の変動を調査し,描写する.
- NHAA集団の中でUCUBの異なる結果を経験する特定のサブグループを特定する.
主な方法:
- サーベイランス,疫学,および最終結果 (SEER) データベースを使用して,UCUBの患者を特定しました.
- 比較分析のために,NHAAコホートを中国,フィリピン,南アジア,日本,韓国,ベトナム,その他のアジアサブグループに分割した.
- 総合生存率 (OS) と癌特異生存率 (CSS) を評価するために,Kaplan-MeierとCoxの比例リスクモデルを使用した.
主要な成果:
- NHAA患者 (n=2,686) は,他の人種/民族グループと比較して,最も長い平均生存期間 (88ヶ月) を示した.
- NHAAサブグループ内の5年間のOS率は50% (フィリピン人) から64% (他のアジア人) であった.
- 調整された分析では,非ヒスパニック系白人患者と比較して,中国人 (HR 0. 84),韓国人 (HR 0. 74) および他のアジア人 (HR 0. 68) 患者の死亡リスクが低かったことが明らかになった.
結論:
- フィリピン系アメリカ人のUCUB生存率は比較的に低い.
- 中国人と韓国人のアメリカ人は,より好ましいUCUBの予報を示した.
- 発見は,文化に合わせた介入と,UCUB管理における健康の公平性を達成するためのリスクの階層化の改善の必要性を強調しています.
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