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Updated: Sep 9, 2025

Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
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Published on: November 7, 2019

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CUBドメインを含むタンパク質1は,T24細胞の治療抵抗に寄与するゲムシタビン代謝を調節する

Kun-Lin Hsieh1, Kuan-Hua Huang1, Ching-Ping Chang2

  • 1Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.

PloS one
|September 2, 2025
PubMed
まとめ

CUBドメインを含むタンパク質1 (CDCP1) は,アポトーシスを抑制し,薬物の代謝を変化させることで,尿路がん (UC) のゲムシタビン耐性を誘発する. CDCP1を標的とした治療は,UC治療においてゲムシタビンの感受性を回復させる可能性がある.

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