同時に発生するクロモブラストミコシスとエウミセトーマ:アジアにおける二重の無視された熱帯性真菌疾患のユニークな事例
Wentao Liu1,2, Shuxia Xie1, Guoxing Zhu1
1Department of Dermatology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
PLoS neglected tropical diseases
|September 2, 2025
まとめ
この症例報告は,忘れられた熱帯病であるクロモブラストミコシス (CBM) とミケトーマを同時に診断された患者の最初の事例を詳細に述べています. 早期発見とヴォリコナゾールによる治療により,患者の状態は改善しました.
科学分野:
- 菌類学
- 感染症
- 熱帯 医学
背景:
- クロモブラストミコシス (CBM) とミケトーマは,見捨てられた熱帯病 (NTD) と指定されたインプラント菌です.
- これらの2つの異なるNTDを患者で同時に感染することは非常にまれです.
研究 の 目的:
- 一人の患者でCBMとミケトームの同時発生を報告する
- この珍しい共感染の 臨床的表象と診断と治療を強調します
主な方法:
- 皮膚病変の組織病理学的検査
- 病原体識別のための真菌培養と次世代メタゲノムシーケンシング
- 臨床診断と治療の監視
主要な成果:
- 69歳の女性の左手にはCBM (Fonsecaea monophora) があり,左下肢にはミセトーマ (Scedosporium dehoogii) がありました.
- ヴォリコナゾールによる治療は,両方の状態の漸進的な改善をもたらしました.
- このケースは,これらの特定の真菌によって引き起こされる同時発生CBMとeumycetomaの報告された最初の例です.
結論:
- CBMとミケトームの同時発生は稀ですが,迅速な診断が必要です.
- このケースは 放置されたインプラント菌の 臨床的なスペクトルに 新たな洞察をもたらします
- 早期発見と適切な抗真菌治療は,これらの共感染の管理に不可欠です.
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