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Updated: Sep 9, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

261

MAPKとmTORC1のシグナリングは,メラノーマの持続性のある細胞に細胞サイクル再侵入を可能にするため,サイクリンD1タンパク質の生産を推進するために収束する

Varuna Nangia1,2, Humza Ashraf1, Nasreen Marikar1

  • 1Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.

Science signaling
|September 2, 2025
PubMed
まとめ

薬剤耐性メラノーマ細胞は,ERKとmTORC1のシグナル伝達経路を再活性化することで,治療を逃れる. この収束はサイクリンD1タンパク質を増加させ,薬の脱出メカニズムを早期に予測し標的化することを可能にします.

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