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Updated: Sep 9, 2025

Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats
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主要な感覚神経におけるGαqシグナリングは,オピオイド鎮痛をNMDA受容体主導の耐性および過敏症にシフトさせます

Daozhong Jin1, Hong Chen1, Meng-Hua Zhou1

  • 1Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Science signaling
|September 2, 2025
PubMed
まとめ

Gタンパク質のGαqシグナリングは,NMDA受容体を活性化することによって,オピオイド誘発の過敏症を引き起こす. Gαqを阻害すると,痛みの緩和が促進され,耐性が低下し,より安全なオピオイド鎮痛剤の新たな標的となる.

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