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Updated: Sep 9, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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抗発作薬がシナプス膀タンパク質2A (SV2A) に結合するアロステリック調節の基礎となるメカニズム

Anshumali Mittal1, Matthew F Martin1, Laurent Provins2

  • 1Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15213.

Proceedings of the National Academy of Sciences of the United States of America
|September 2, 2025
PubMed
まとめ

UCB1244283は,抗発作薬がシナプス膀タンパク質2A (SV2A) に結合することをアロステリックに強化する. この発見は新しい結合部位とネットワークを明らかにし,新しいSV2A標的治療法への道を開きます.

キーワード:
アロステリー膜タンパク質薬理学について構造生物学

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