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Updated: Sep 9, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
09:11

Assays for Validating Histone Acetyltransferase Inhibitors

Published on: August 6, 2020

6.6K

非ヒドロキサマートベンゾ酸ベースの微生物を潜在的ヒストン脱酸化酵素阻害剤 (HDACi) として合成し,生物学的評価

Nedaa A Abd Al Rahim1, Ammar A Razzak Mahmood1, Lubna H Tahtamouni2,3

  • 1Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

Chemistry & biodiversity
|September 2, 2025
PubMed
まとめ

研究者らは,ベンゾ酸ベースの新しいヒストン脱酸化抑制剤 (HDACi) A3bnを開発しました. この化合物は,FDAが承認した薬に匹敵する有効性を示し,癌細胞の成長を抑制し,アポトーシスを誘発し,改善された特性を有する有望な代替品を提供します.

キーワード:
シフ・ベースアポトーシス阻害剤オクサジアゾールチオアミド

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