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Updated: Sep 9, 2025

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

7.8K

トランスチレチンタンパク質の構造安定性に対するG83R変異の影響

Xingwang Chen1,2,3,4,5, Junlin Pan2,3,4,5, Xiaomei Nie1,6

  • 1Suzhou Medical College, Soochow University, Suzhou 215021, China.

ACS omega
|September 2, 2025
PubMed
まとめ

G83Rトランスチレチン (TTR) 変異は,TTRタンパク質の構造と動態を不安定化し,アミロイド線維の形成を増加させます. この研究は,TTRに関連するガラスのアミロイドーシスの病原性メカニズムを明らかにしています.

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