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Updated: Sep 9, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

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WEE1阻害剤とビタミンK2の組み合わせは,慢性骨髄性白血病の治療効果を高める

Seiichi Okabe1, Yuya Arai1, Akihiko Gotoh1

  • 1Department of Hematology Tokyo Medical University Tokyo Japan.

Cancer innovation
|September 2, 2025
PubMed
まとめ

WEE1阻害剤MK- 1775をビタミンK2 (VK2) と併用すると,TKI耐性を含む慢性骨髄性白血病 (CML) の治療に有望であることが示されています. この新しいアプローチはCML細胞を標的にし,アポトーシスを誘発し,生存能力を低下させます.

キーワード:
WEE1 阻害剤慢性骨髄性白血病ビタミンK2

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