腸内短鎖脂肪酸の循環は,健康な成人のメソリンビックドーパミンネットワークにおける休息状態の機能的接続性とは関連していない
Madelief Wijdeveld1, Anouk Schrantee2, Júlia Tolra Azor1
1Department of Internal and Experimental Vascular Medicine, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands.
Neuroimage. Reports
|September 2, 2025
まとめ
短鎖脂肪酸 (SCFA) は,報酬経路における腸内微生物群と脳の接続性との関連を媒介するものではありません. この研究では,SCFAの転用と健康な個体における機能的接続性との間には関連性が見出されなかった.
科学分野:
- 神経科学
- 胃腸内科
- 代謝に関する研究
背景:
- 肥満は脳の報酬システムの 接続性の変化と関連しており 腸-脳軸が媒介する可能性があります
- 腸内微生物群によって生成される短鎖脂肪酸 (SCFA) は,この腸-脳通信の中間物質であると推測されています.
研究 の 目的:
- 報酬に関連する脳の領域の休息状態の機能的接続性に対するSCFAの転移の影響を調査する.
- 腸内微生物群と脳の機能的接続性との関係を媒介するかどうかを判断する.
主な方法:
- 腸内SCFA回転が非常に高いまたは低い健康な個体 (ButCoA遺伝子の糞便濃度で推定) を採用した.
- 主要な報酬ネットワーク領域における機能的接続性を評価するために,静止状態の機能的磁気共鳴画像 (rs-fMRI) を利用した.
- アミグダラ,ヒポカンプス,インスラを含む領域で測定された接続の強さと自己ベクトルの中心性.
主要な成果:
- 接続の強さや自己ベクトルの中心性は,高と低のSCFAターンオーバーグループ間で有意な違いが見つかりませんでした.
- 賞与に関連する脳の領域の休息状態の機能的接続性とは関係なかった.
結論:
- この研究は,SCFAが腸内微生物群と中央報酬領域の機能的接続性との関連を媒介するという仮説を支持しません.
- 局所的なSCFA生産を超えた代替メカニズムは,腸内微生物群が食欲と脳機能にどのように影響するかを説明する可能性があります.
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