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Updated: Sep 9, 2025

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

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WACの阻害は,H2BK120ub1とH3K27me3の同調によって,コンドロサイトの炎症性分泌フェノタイプと軟骨の分解を緩和する

Peitao Xu1, Guiwen Ye1, Xiaojun Xu1

  • 1Department of Orthopedics, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518003, China.

Acta pharmaceutica Sinica. B
|September 2, 2025
PubMed
まとめ

WWドメインを含むアダプタータンパク質 (WAC) は,炎症媒介体を調節することによって,関節炎における軟骨の分解を誘導する. WACをドクサーカルシフェロールで標的化することは,関節リウマチや関節炎における関節破壊のための潜在的な治療戦略を提供します.

キーワード:
関節炎軟骨の劣化コンドロサイト分泌ドクサーカルシフェロールヒストンの改変炎症分子ドッキングとダイナミックシミュレーションWAC について

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