炎症性腸疾患患者における刺激性腸症候群:流行,病因,治療
David J Gracie1, Alexander C Ford1,2
1Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, United Kingdom.
Gastroenterology & hepatology
|September 2, 2025
まとめ
炎症性腸疾患 (IBD) の多くの患者は,刺激性腸症候群 (IBS) に似た持続的な胃腸症状を経験します. 脳と腸の軸をターゲットにすると 症状と生活の質が改善されます
科学分野:
- 胃腸内科
- 神経胃腸内科
- 精神胃腸内科
背景:
- 静止性炎症性腸疾患 (IBD) の患者の有意な割合は,刺激性腸症候群 (IBS) に類似する持続的な胃腸症状を報告しています.
- IBDにおけるこれらのIBS型症状は,心理的苦痛,生活の質の低下,および医療の使用量の増加と関連しています.
- 脳と腸の軸は,中枢神経系と胃腸機能の関係に関与し,これらの症状を媒介する可能性があります.
研究 の 目的:
- 静止性IBD患者のIBS型症状の流行,影響,病因,および治療をレビューする.
- IBDの病理生理学と症状報告における脳腸軸の役割を強調する.
- この患者群で脳腸軸を標的とした治療法を調査する臨床試験の必要性を強調する.
主な方法:
- 観察研究と既存の証拠の文献レビュー
- IBDにおける気分,炎症,腸-脳軸機能の関係に関する分析.
- 食事の操作,神経調節剤,行動療法を含む潜在的な治療戦略の検討.
主要な成果:
- 観察データはIBDにおける気分と炎症活動との関連を示唆し,脳-腸軸の役割を強調しています.
- IBD患者における脳腸軸療法に関する現在の証拠は限られている.
- IBDの治療と脳腸軸の介入を組み合わせた統合された管理アプローチは有望である.
結論:
- 静止状態のIBDの患者は,IBS型の症状を頻繁に経験し,健康に影響します.
- IBDの治療と共に 脳と腸の軸をターゲットにすることで これらの症状を緩和する 戦略が考えられます
- IBDにおける脳腸軸の治療法を検証するには,さらなる研究と臨床試験が必要である.
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