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ヒト感染モデルにおける症状と有害事象

Karen Götz1, Poleta Luga1,2,3, Jörg Rengel1

  • 1Division of Infectious Disease, Paul-Ehrlich-Institut, Langen, Germany.

Frontiers in medicine
|September 2, 2025
PubMed
まとめ

No abstract available in PubMed .

キーワード:
CHIM について副作用抗感染剤人間に挑戦する試験安全性についてワクチン

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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