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Updated: Sep 9, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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カルバマート前薬は,生体代謝を抑制し,イソニアジドの薬動性を改善する

Jishnu Sankar1,2, Manish Kumar Bajpai1, Anjali Chauhan1

  • 1Centre for Drug Discovery, BRIC-Translational Health Science and Technology Institute, Faridabad, Haryana 121001, India.

ACS central science
|September 2, 2025
PubMed
まとめ

新しいイソニアジド前薬は 毒性を軽減し 結核の治療を改善するために 反応性アミン群を隠します 鉛前薬1dは,より高い曝露と,より長い半減期を示し,より安全で効果的な結核治療を約束しています.

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