環境への毒性物質の暴露に関する毒性遺伝学的洞察:ターゲットIIリソース
Research square
|September 2, 2025
まとめ
幼少期に有毒化学物質に 曝されることで 長期にわたる 遺伝子の変化が起こります トランスクリプションII (TaRGET II) のゲノム系およびエピゲノム系レギュレータによる毒性物質暴露および反応は,これらの効果を研究するための公共のリソースを提供します.
科学分野:
- 環境エピジェネティクス
- トキシゲノミクス
- 分子毒理学
背景:
- 環境中毒物質は 遺伝子発現と表遺伝子調節を 妨げる可能性があります
- これらの障害は 生命体の生涯にわたって 病気を引き起こす可能性があります
- 生命の初期に被曝した物質の 長期的分子の影響を理解することは 極めて重要です
研究 の 目的:
- 毒性物質のエピジェノミクスとトランスクリプトミクスに関する詳細な情報源を作成する.
- これらの分子変化の持続性と特異性を調査する.
- 環境への曝露と病気との関連を研究するためのアクセス可能なデータを提供すること.
主な方法:
- 特定の毒性物質 (ヒ素,鉛,BPA,DEHP,TBT,TCDD,PM2.5) に曝露したマウスでの長期研究.
- 異なる生命段階の複数の組織から2,570のエピジェノームと1,043のトランスクリプトームを生成する.
- DNAメチル化,クロマチンのアクセシビリティ,遺伝子発現パターンの分析.
主要な成果:
- エピゲノムとトランスクリプトームの持続的,毒素特異的,性依存的変化を特定した.
- 広範な遺伝子発現障害 (14,908遺伝子),クロマチンのアクセシビリティの変化 (87,409要素),DNAメチル化変化 (113,186領域) が観察されました.
- 毒性物質の曝露に反応するクロマチンの状態の変化を記録した.
結論:
- 幼少期の環境への曝露は エピゲノムとトランスクリプトームを 永続的に再プログラムすることができます
- TaRGET IIのリソースは,これらの分子変化の高解像度マップを提供します.
- 公に公開されたこのデータは 環境に起因する疾患の病原性に関する研究を容易にする.
さらに関連する動画
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
2.8K
09:33Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
7.5K
関連する概念動画
Toxic Reactions: Overview
1.2K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.2K
Types of Toxins
2.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
2.0K
Mutagenicity and Carcinogenicity
1.4K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.4K
Gene-Environment Interactions
433
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
433
Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation
368
Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
368
