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Updated: Sep 9, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
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先進性非小細胞肺がんの治療における第1世代の表皮成長因子受容体阻害剤と第3世代の表皮成長因子受容体阻害剤の比較分析:体系的レビューとメタ解析

Siyan Peng1,2, Zhixin Yu1,2, Honglin Zhu1,2

  • 1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Frontiers in pharmacology
|September 2, 2025
PubMed
まとめ

第1世代のEGFRTKIと化学療法 (1GTKIと化学療法) は,進行性非小細胞肺がんにおける第3世代のEGFRTKI (3GTKI) と比較可能な無進行生存率と全生存率を示しています. この組み合わせはより高い反応率をもたらしますが,有害事象も増加します.

キーワード:
EGFR ミュータント進行した非小細胞肺がん化学療法併用療法標的型療法

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