AHA's Life's Essential-8 日本人の心臓血管の健康指標と冠動脈カルシフィケーションの進行
Rajib Mondal1, Aya Kadota1,2, Yuichiro Yano3
1Department of Preventive Medicine, NCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
American journal of preventive cardiology
|September 2, 2025
まとめ
ライフ・エッセンシャル8 (LE8) で測定される低心血管健康スコアは,日本人の男性における冠動脈カルシフィケーション (CAC) の増加と進行に関連しています. 動脈硬化症の予防には 最適なLE8指標の維持が不可欠です
科学分野:
- 心臓病科
- 予防 医療
- 公衆衛生
背景:
- アメリカン・ハート・アソシエーションのライフ・エッセンシャル8 (LE8) メトリックは,心血管の健康 (CVH) を評価します.
- LE8 CVHと亜臨床性動脈硬化,特に冠動脈化 (CAC) の進行との関連は不明である.
- この研究では,日本人の男性におけるLE8 CVHとCACの関係を調査した.
研究 の 目的:
- 日本人の男性における冠動脈カルシフィケーション (CAC) の流行および進行とのLE8心血管健康指標の関連性を調べる.
- 低LE8スコアが亜臨床性動脈硬化症のリスク増加と相関するかどうかを判断する.
- アジア人の心血管リスクの評価における LE8 の役割についての洞察を提供するためです.
主な方法:
- 760人の無症状の日本人の Shiga Epidemiological Study of Subclinical Atherosclerosisのデータを分析した.
- ライフ・エッセンシャル8 (LE8) の心血管健康 (CVH) のスコアは,8つの要素に基づいて低 (0 - 49),中等 (50 - 79) および高 (80 - 100) と分類された.
- 冠動脈カルシフィケーション (CAC) は,ベースラインおよび5年後に定量化され,流行および進行は,修正されたポアソン回帰を用いて評価された.
主要な成果:
- CACの高頻度 (63. 2%) とCACの進行 (44. 9%) が,それぞれベースラインおよびフォローアップで観察されました.
- LE8のCVHスコアが中等で低い個人は,高いCVHスコアを持つ個人に比べて,CACの有病性のリスクが著しく高かった.
- 5年間の追跡期間中のCAC進行のリスクも著しく高かった.
結論:
- Lower Life' s Essential 8 (LE8) の心血管健康 (CVH) のスコアは,冠動脈カルシフィケーション (CAC) の流行と進行の両方のリスクの増加と有意に関連しています.
- これらの発見は,一般的な日本人の男性集団における亜臨床性動脈硬化症の予防のための最適なLE8指標の重要性を強調しています.
- LE8の枠組みは,心血管疾患の進行のリスクが高い個人を特定するための貴重なツールとして役立つかもしれません.
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